The Power of Polyneucleotides in Aesthetics

Dr Yannis is a triple board-certified Plastic Surgeon, Founder and Medical Director of 111 Harley St., specialising in Facelifts and Neck Lifts in London’s highly respected medical area. Under his expert guidance, the clinic offers plastic surgery procedures, aesthetic treatments, and injectables, incorporating the latest technologies and techniques.

What Are Polynucleotides?

As a Plastic Surgeon at a leading clinic on Harley Street, I am always seeking the next great aesthetic innovation and monitoring trends to understand what people want from their treatments. Recently, there has been a notable shift towards achieving natural results and increased demand for collagen-stimulating treatments that work with the body’s processes.

We introduced bio-stimulating polynucleotides to 111 Harley St. in 2022 and were immediately impressed with the results. These treatments, often combined with other advanced injectables, allow patients to maintain youthful skin, improve texture, and promote long-term collagen production.

Dubbed the ‘Salmon Sperm Treatment’ by the media, polynucleotides are natural biological compounds derived from DNA or RNA and have remarkable healing properties. When injected into the skin, they stimulate cellular repair, improve texture, and address various signs of ageing. Polynucleotide treatments stand out due to their ability to improve skin appearance in the short term while promoting long-term rejuvenation.

Polynucleotide Injections in Facial Rejuvenation

Polynucleotide injections are particularly effective for treating delicate facial areas, such as the mid-face and under-eye region, which often show early signs of ageing. These injectables promote cell regeneration and increase collagen and elastin synthesis, producing a powerful reparative effect on skin cells. This revitalisation restores skin vitality, improving texture and elasticity diminished by ageing.

Patients often seek treatment for under-eye concerns, such as dark circles and ageing signs. The thin, delicate skin under the eyes becomes thinner as collagen production decreases, leading to fine lines and wrinkles. Polynucleotides effectively stimulate collagen in this area.

Previously, Tear Trough Fillers were the only non-surgical option for under-eye hollowness, but they aren't suitable for all patients. Tear Trough Fillers, which are hyaluronic acid-based, can exacerbate swelling in patients with oedema. Polynucleotide treatments offer an effective alternative.

In the mid-face region, including the cheeks and nasolabial folds, collagen stimulation can restore volume and restructure the skin, resulting in a natural lift. I typically recommend a minimum of two treatments, with results continuing to build 6–8 weeks post-treatment.

Hybrid Injectables: The Next Step in Facial Rejuvenation

Hybrid injectables are a growing trend in facial aesthetics. For example, HArmonyCa combines the volumising power of dermal fillers with the long-term anti-ageing benefits of bio-stimulants. These treatments address crepiness in mid-facial zones and effectively treat hollowness.

Hybrid injectables often combine polynucleotides with hyaluronic acid (HA) to hydrate and plump the skin. HA provides immediate hydration and volume, while polynucleotides work on deeper layers to stimulate long-term collagen production. This combination ensures natural, balanced results.

At 111 Harley St., we approach consultations and treatment plans bespoke to each patient. Polynucleotides and their hybrid counterparts are becoming integral to our offerings, such as the 111GlassSkin treatment, a Korean-inspired injectable treatment that uses a combination of products to achieve a radiant, glassy finish.

Bio-Collagen Stimulation and Skin Regeneration

The core benefit of polynucleotide treatments lies in their ability to stimulate bio-collagen production. Collagen is crucial for skin structure and firmness, which diminishes with age, causing laxity, lines, and wrinkles.

Polynucleotide injections combat these issues by encouraging fibroblasts, the cells responsible for collagen production, to increase activity. This bio-stimulation process yields natural-looking results that improve over time, enhancing skin texture and tone while promoting a youthful, radiant complexion.

As aesthetics evolve, I anticipate polynucleotides growing in popularity, similar to the rising demand for Micrografting, which uses the body’s own fat as a long-lasting filler alternative. Offering these cutting-edge options enables my team to tailor treatments to each patient’s unique needs.